Recent Developments emerging in the Amyotrophic Lateral Sclerosis and Its Treatment Landscape



What is Amyotrophic Lateral Sclerosis?

 A disorder of the neurological system that impairs physical function and weakens muscles is called Amyotrophic Lateral Sclerosis (ALS).

The amyotrophic lateral sclerosis treatment environment is strict and includes multidisciplinary care, such as physical therapy, speech therapy, food counselling, heat or whirlpool therapy, and other procedures. Amyotrophic lateral sclerosis can be treated with the following drugs: RILUZOLE, RADICAVA, TIGLUTIK, EXSERVAN, and RELYVRIO. ALS-related disease progression cannot currently be slowed down or stopped by any effective treatment. The cornerstones of ALS treatment are palliative care and symptom management.


RADICAVA, the first Amyotrophic Lateral Sclerosis medication in decades since Riluzole approval with an eye-popping price tag

RADICAVA (edaravone), the second drug used to treat ALS patients, decreases the loss of physical function in ALS patients. Despite being used to treat acute stroke in Japan since 2001 under the brand name RADICUT, it took close to 20 years for RADICAVA to be approved for the treatment of ALS. It was authorised for the treatment of acute stroke in Japan in June 2015 and in South Korea in December 2015 based on a number of ALS clinical trials carried out in Japan.

The US FDA was so impressed with Mitsubishi's medicine after learning that edaravone was being used to treat ALS in Japan that it contacted Mitsubishi right away to discuss submitting a marketing application in the US.

What is expected from the ALS treatment market in the future?

Today's market for ALS treatments is largely comprised of approved drugs like RADICAVA, RELYVRIO, and various riluzole formulations. On the other hand, NUEDEXTA only addresses symptoms; it has no effect on stopping the illness's progression. Promising mid- and early-phase therapies for ALS include RNS60 (Revalesio Corporation), EPI-589 (PTC Therapeutics), AT-1501 (Eledon Pharmaceuticals), AP-101 (AL-S Pharma), ANX005 (Annexon), Pegcetacoplan (Apellis Pharmaceuticals), PrimeC (NeuroSense Therapeutics), and BIIB078. While there are several promising ALS medicines in various stages of development, there have been many ups and downs and unsuccessful clinical studies throughout the history of ALS pipeline development.

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